Amino Acid Matrix, POWERFUL Substrates
Detailed FORMULA FACTS and Exclusive Product Access
Synthagen Suggested Use:
athletic and recovery benefits, take 4-8 capsules immediately prior and post exercise, and/or before sleep with 10 oz of juice (cherry/tart styles being best) or water.
For peak nutrition optimization and to boost cellular repair, muscle recovery, protein synthesis and anti-aging/life enhancement benefits,
take 2-4 capsules 10 minutes before meals.
Note: MASS PRO Synthagen closes the gap between safe, smart supplementation and harmful performance drugs like never before. It works so well some may question, but be assured this elite natural formula is 100% drug/hormone-free and equally effective for both sexes without restriction.
While this product will allow one to increase workout frequency and decrease calorie intake simultaneously, it is not suggested to serve as a meal replacement nor should scheduled off days from training be totally eliminated - no matter how tempting it may be!
L-Leucine, L-Lysine, L-Phenylalanine, L-Valine,
L-Threonine, L-Isoleucine, L-Methionine, L-Histidine, L-Taurine, L-Tryptophan
Discover the POWER of ProtoGeneX™ for yourself.
Proprietary, 10+ Amino Acid Matrix
A discussion on optimizing nutrition and protein synthesis must include the essential amino acids.
For, if even a single EAA is missing, no muscle can be built or repaired (1)
- hence the term, "essential".
(1) Net muscle protein synthesis results from
ingestion of essential amino acids (Tipton et al., 2001, 2003; Borsheim
et al., 2002).
This is a critical point, because the proprietary MASS PRO Synthagen™ formula provides ALL of the essential amino acids in
proven potencies and in circulation concurrently with very powerful
substrates to optimally leverage omni-potent effects, in particular vastly accelerated protein synthesis.
Branched Chain Amino
Acids (BCAA) also spike protein synthesis, so for maximum results a strong shot of the "tested positive" proprietary BCAA's as found in MASS PRO
Amino are included.
The BCAA's are key signaling agents, and the full ProtoGeneX (proto-gene-ten) Amino Acid Matrix literally floods your cells with every single amino acid proven to build, repair and replenish muscle tissue.
BOTTOM LINE: MASS PRO Synthagen delivers strong protein synthesis signaling while providing the "building blocks" and elite substrates that grow new muscle - precisely when and where your body
needs them most.
is ProtoGeneX verses whole proteins?
The net nitrogen utilization of ProtoGeneX far exceeds that of any intact (peptide bonded) protein
source. In fact, it has been shown that
12g of EAA's alone more than
doubled muscle amino acid uptake, vs. 20g of "intact" proteins like
caseinate or egg (2). What
does this mean? It means less metabolic waste in the form of urea,
ammonia, bloating and gas.
MASS PRO Synthagen with ProtoGeneX Amino Acids is infinitely more efficient, delivering much greater protein synthesis - without the detrimental and growth retarding hindrance of metabolic waste byproducts.
(2) Borshein et. al. 2002, Tipton et.al. 2004
What makes the specific ProtoGeneX amino stack best?
To answer this question, we need only look at what just 6 grams of EAA's is able to accomplish.
Research published in two prestigious medical
publications, the American Journal of Physiology (Endocrinology and Metabolism) and Journal of Sports Sciences, shows human subjects given 6 grams of a specific essential amino acid blend before weight training increases protein
synthesis by almost 600%.
So what is so special about
this amino acid blend that caused such a huge increase in muscle protein synthesis? The answer is in the unique amino acid profile, and the timing of its administration.
Further, this EAA ratio does
NOT require any carbohydrates to exert its effects on muscle protein synthesis!
Also, as a vital side note: The unique EAA ratio as seen in the ProtoGeneX blend contains perfect amounts of the ONE essential amino that other sports nutrition companies seemingly don't even know exists!
More on this in a special report, soon.
The point is, every scrap of scientific data has been expertly scrutinized and applied from these studies and others to arrive at the proprietary ProtoGeneX Amino Acid profile. No stone has been left unturned, including one very important NON-ESSENTIAL "amino acid" that scores an excellent grade...
The merits of L-Taurine are profound within the ProtoGeneX Amino Acid Matrix. Here's the top 4:
1.) Taurine mimics the
effects of Insulin (3)
NOTE: An insulin surge isn't what's desired here, nor does it occur
with Taurine. Rather, an effect mimicking insulin is what we're after
(independent of carbohydrate ingestion). The benefits are twofold: An
effect mimicking insulin slows muscle tissue breakdown, and also serves
to shuttle MASS PRO Synthagen's payload directly into your muscle
2.) Reduces Appetite (3)
There is an appetite reduction effect seen with Taurine, which
contributes further to fat loss.
3.) Quadrupled Hypothalamic mTOR Activity (major muscle growth mechanism) (3)
This recent finding is a most exciting one. mTOR activity is a MAJOR player in muscle growth, and Taurine's ability to modulate this in the hypothalamus is significant. While other ingredients in the complete MASS PRO Synthagen complex accomplish this elsewhere in the body,
Taurine's ability to do this in the brain is unique.
4.) Cellular Hydration
The final attribute Taurine brings is in maintaining muscle cell
hydration. As the 2nd most abundant amino acid in muscle tissue, its
presence is warranted to maximize cellular hydration - which is a potent anabolic signal in itself, given that muscle is roughly 70% water.
RCE optimizes nearly every body function...
As the most exotic ingredient
in MASS PRO Synthagen, Rhaponticum
Carthamoides Extract (RCE) is an incredibly rare, powerful compound.
A serving of Synthagen caps contain a specific portion of the very same
proven potent FULL-SPECTRUM '10 levseins' RCE
as found in Kre-Anabolyn, the Ecdysterone Gold Standard.
In addition to a specific
ratio of ecdysterones, '10 levseins' RCE boasts
tannins and resins not found in other ecdy genus. For example, one of
these tannins mitigates your body's ability to convert carbohydrate to
The effect on messenger
RNA Translation/Translocation, however, is what MASS PRO Synthagen most
seeks to optimize. Specifically, RCE has the ability to speed up the
activity of the muscle cell cytoplasm/ribosome - leading to an
accelerated rate of Translation and Translocation (4,5).
As well, a
recent study showed that "Ecdy
elicited a rapid elevation in intracellular calcium, followed by
sustained Akt activation and increased protein synthesis"
(6). It allows for an increase in both
the number and activity of
ribonucleic acids and the forming of new contractile muscle proteins
available amino acids.
(4) Syrov VN.
Mechanism of the
anabolic action of phytoecdysteroids in mammals. Nauchnye Doki Vyss
Shkoly Biol Nauki (11), (1984): pages 16-20.
(5) N. Todorov,
MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG
ACTIONTHE EFFECT OF ECDYSTERONE ON THE BIOSYNTHESIS OF PROTEINS AND
NUCLEIC ACIDS IN MICE. Translated from Khimiko-Farmatsevticheskii
Zhurnal, 34 (9), (Sep. 2000): pages 3-5.
2010;75:632 637 -
Gorelick-Feldman J, Cohick W, Raskin I. Ecdysteroids elicit a rapid
Ca2+ ux leading to Akt activation and increased protein synthesis in
skeletal muscle cells.
So, building upon the
strength of ProtoGeneX aminos, RCE allows us to increase both the
number and activity of ribonucleic acids and
the forming of new contractile muscle proteins.
To be clear, any discussion
about optimizing RCE's protein
synthesis attributes must also include the essential amino acids.
even a single essential amino is missing, no new muscle will be built
In addition to RCE's ability
to supercharge protein synthesis, it optimizes nearly
every bodily function.
The following list of
attributes are some of the positive, health promoting benefits conveyed:
• Improves the body's ability to stabilize blood sugar
• Stimulates incorporation of glycogen into both liver
• Repartitions nutrients into muscle and organ tissue
yielding better muscle growth and repair
• Possesses potent cholesterol-lowering effects
• Stabilizes phospholipid membranes, positively linked
to many health benefits
• Cholesterol lowering/effects on bile secretion imparts
excellent benefits to the liver
• Analgestic, anti-inflammatory and potent antioxidant properties
• Anti-arrhythmia stabilizing effects
• Positive skin improvements: keratinization,
differentiation and acne
• Controls cortisol by reducing stressors such as
• Increases athletic performance by increasing work and
• Generates a more favorable oxygen/CO2 exchange under
lean muscle tissue weight and reduces fat
• Combats fatigue/apathy
cartilige growth and repair in joints
positive nitrogen balance and maintains a greater rate of protein
BOTTOM LINE: Long
time Kre-Anabolyn fans attest to many of the above results. With such broad benefits established, let's now look at the other complimentary/synergistic
nutrients in MASS PRO Synthagen.
Like Ecdysterone, there were several studies done on Orotic Acid (OA)
in the former Soviet Union by Meerson, et al in the 1960's, showing
ergogenic effects as it relates to exercise (7). Other
studies provide evidence of its attributes based on animal models,
including accelerated skeletal muscle hypertrophy (muscle growth)
following supplemental Orotic Acid. Further work by the Meerson's group
demonstrated enhanced swimming performance as a function of muscle
hypertrophy and energy supply following Orotate supplementation.
(7) Meerson FZ, Rosanova LS. (1967) Effect of
2703 actinomycin and combination of nucleic acid synthesis activators
on the development of fatigue and fitness. Doki. Akad. Nauk. SSSR: 166:
Let's learn more...
OA can be thought of as a
non-hormonal anabolic agent, naturally present in the body and having a
general stimulating effect on the metabolism. In particular, it
stimulates the synthesis of nucleic acids involved in protein
synthesis, and enhances repair and regenerative processes in many
Scientific studies have shown
OA to be extremely helpful to athletes. It is unique in its ability to
optimize many of the bodily functions critical for strength. Orotic
Acid spikes protein synthesis and thus accelerates muscle growth. It
increases the ATP production, Creatine and Carnosine leading to greater
strength and endurance. It promotes glycogen
storage and optimizes oxygen usage, resulting in greater VO2 max.
OA augments protein
synthesis/muscle hypertrophy and maximizes protein synthesis on all
critical levels. It also plays an active role in DNA/RNA synthesis and
was found to augment muscle hypertrophy (8,9).
(8) Meerson FZ. (1969) The myocardium in
hyperfunction, hypertrophy and heart failure. Circ.Res. 24/25
(Suppl.2): II146 - II155.
(9) Meerson FZ, Rosanova LS. (1967) Effect of 2703 actinomycin and
combination of nucleic acid synthesis activators on the development of
fatigue and fitness. Doki. Akad. Nauk. SSSR: 166: 496-499.
A study conducted at the Justus-Liebig University with
triathletes in 1998 showed that Orotic
Acid improved power, endurance and performance. The testing
demonstrated a remarkable increase in oxygen and glucose metabolism,
while cortisol and carbon dioxide levels were dramatically reduced.
These results were impressive
as they represented a significant difference vs. the placebo group.
Orotic Acid´s ability to increase ATP production and regeneration
in an oxygen-depleted environment (i.e. weight training) is especially
impressive. Better Glucose disposal optimizes Glycogen storage. More
glycogen = faster gycolysis, which as we'll see later on offers BIG
There is still LOTS more...
The positive influence of
Orotic Acid on ATP levels (10,11)
(10) Richards SM, Conyers RAJ, Fisher JL,
Rosenfeldt FL. (1997) Cardioprotection by Orotic Acid: Metabolism and
mechanism of action. J.Mol.Cell.Cardiol. 29: 3239-3250.
(11) Williams JF, Donohoe J, Lykke A, Kolos G. (1976) Studies using
orotic acid for improving the controlled development of myocardial
hypertrophy. Aust.NZ.J.Med. 6 (Suppl.2): 60-71.
OA increases nucleotide pools and cellular energy stores (12)
(12) Kypson J, Hait G, Mathew R. (1978) Effects of uridine on
the performance and the metabolism of oxygenated and hypoxic rabbit
hearts. J Mol Cell Cardiol. 10: 545-565.
Orotic Acid increased ribose moieties (R-1-P & R-5-P) leading to
enhanced ribose formation (13)
(13) Olivares J, Rossi
A. (1982) Incorporation of orotic acid in myocardial uridine
nucleotides: effect of isoproterenol and ribose. J.Physiol. (Paris).
OA increases muscle carnosine stores (14)
(14) Aonuma S, Hama T, Tamaki N, Okumura H.
(1969) Orotate as a -alanine donor for anserine and carnosine
biosynthesis and effects of actinomycin D and azauracil on their
pathway. J.Biochem. 66: 123-133.
But, how safe is Orotic Acid?
Orotic Acid is naturally produced by the body in small amounts, and is
considered an extraordinarily safe substance. Orotic Acid is found
naturally in mother's milk and, in miniscule quantities, in other
Orotates are organic compounds, ready to be optimally metabolized by the cell.
Orotate-compounds have been used in orthomolecular medicine for decades
to increase bioavailability of minerals and trace elements.
NUCLEOTIDE POOLS - Why it is important
Pyrimidine nucleotides are components of phospholipids (structural
parts of the muscle cell membrane). These nucleotides exist in pools
and are absolutely critical to keep "topped off". Given as ATP demands
increase during hard training - there is a corresponding decrease in
total adenine nucleotides and total pyrimidines (TPN = cytosine,
uridine and there phosphate bound metabolites). So let's break it down
PROBLEM: Depletion of these pools during exercise decreases the energy
generating capacity of muscle
SOLUTION: Orotic Acid builds up nucleotide pools in muscle
tissue, and enhances muscle contractile force
Several studies demonstrate OA's ability to boost these
pools. For example, Richards et al. (15) shows that OA boosts the body's nucleotide pool rather dramatically. Following a 2 day loading phase with Orotic Acid, measurements of total
adenine (ATP, ADP, and AMP) pyrimidine nucleotides (cytosine and uridine) were taken with a resultant 121% rise in muscle nucleotides. More recent work on isolated human muscle fibres has shown that elevation of pyrimidine base concentration enhances the contractile capacity of muscle tissue (16).
(15) Richards SM, Conyers RAJ, Fisher JL,
Rosenfeldt FL. (1997) Cardioprotection by Orotic Acid: Metabolism and
mechanism of action. J.Mol.Cell.Cardiol. 29: 3239-3250.
(16) Munsch CM, Williams JF, Conyers RAJ, O'Halloron K, Langley LH,
Rosenfeldt FL. The effect of orotic acid and ribose on the impaired
tolerance of the recently infracted rat heart to cardioplegic arrest.
In: Williams JF, ed. Orotic acid in cardiology. New York: Thieme
Medical, 1992; 46-58.
In fact, OA is the very first pyrimidine formed in the pathway for
nucleic acids, leading to greater RNA synthesis. Since muscle
growth is HEAVILY dependent upon RNA availability, its worth looking at
just how much RNA is in play while you're growing. There are 3 primary
1. Messenger RNA (mRNA) contains the genetic code or "blueprint" with
which to build new muscle tissue. As in DNA, mRNA genetic information
is encoded in the sequence of nucleotides.
2. Ribosomal RNA (rRNA) is
the building site, or factory where new proteins are assembled (from
amino acids). Every factory needs workers, and that brings us to...
3. Transfer RNA (tRNA) is an
RNA molecule typically
73 to 93 nucleotides in length that is used to bridge the 4 letter
genetic code (ACGU) in messenger RNA (mRNA) with the 20 letter code of
amino acids in proteins.
It's clear then, that the more nucleotides, RNA blueprints, factories,
workers and bricks you have available, the more efficiently you'll be
able to build muscle. By utilizing a precise amount of OA, MASS PRO Synthagen
here in spades - addressing a critical facet of muscle growth ignored
in other formulas.
Perhaps more than any other ingredient, Orotic Acid amplifies the
protein synthesis signaling properties of MASS PRO Synthagen's
RCE/Ecdysterone and ProtoGeneX Amino Acid Matrix. It also brings to the
table a wide safety net, optimizing cellular energy stores,
accelerating wound healing and improving food efficiency (more on this below) via multiple
MASS PRO Synthagen doesn't stop here, though, not by a longshot...
Patented PEAK ATP®
The rate of protein synthesis
is regulated by the cellular energy status in muscle (and even
non-muscle!) cells (17,18). AMP-activated protein
kinase may be thought of as nature's "energy sensor". AMPK is activated
by a fall in ATP (concomitant with a rise in ADP and AMP), which leads
to the activation of catabolic pathways and the inhibition of anabolic
pathways. In plain English- if your body senses it's running low on
ATP/cellular energy, then it won't be building any new muscle tissue.
When the body senses ATP is
in short supply - amino acids are used to form adenosine/guanadino
energy substrates. Creatine for example, can be synthesized by
combining Arginine, Glycine and Methionine if the body senses ATP
levels are low. Note however, that once used by the body for that
pupose they're NOT then available to build new muscle. In this example,
Methionine (an EAA) is being "borrowed" for creatine synthesis and
thus, no new muscle growth will take place.
MASS PRO Synthagen tops off
ATP pools by providing a generous amount of Patented PEAK ATP - the
proven ATP supplement to increase levels of
ATP in the body. Peak ATP also increases the availability of glucose,
nutrients and oxygen in muscles and the brain. This allows for faster
removal of catabolic waste which, in turn, improves both performance
and recuperation while reducing the perception of fatigue/pain.
Supplying the exact molecule the body needs to create energy (adenosine
5' tri-phosphate), this ingredient also increases circulation to the
entire body/brain and has effects far beyond boosting ATP levels. Increased energy, growth, recovery,
strength and mental acuity are noted by users. It is a unique
nutraceutical that has anti-aging, nootropic and life extension
benefits. As a key component in MASS PRO Synthagen, Peak ATP ensures rapid and complete delivery of the
formulas entire payload.
(17) Browne GJ, Proud CG. Regulation of
peptide-chain elongation in mammalian cells. Eur J Biochem 269:
(18) Proud CG. Regulation of mammalian translation factors by
nutrients. Eur J Biochem 269: 5338,5349, 2002. Medline
MASS PRO Synthagen
Maximizes ATP in 3 additional ways
Recall how Orotic Acid was cited as being a complimentary part of
Synthagen's formula, enhancing the effects of its other ingredients?
Here's another great example: Once ATP stores have been optimized in
the cell, OA goes to work making sure things stay that way. It
accomplishes this in 3 different ways...
1.) OA increases the production of ribose moieties (R-1-P and R-5-P).
These are necessary for the salvage/de novo synthesis of purine
nucleotides by a process know as "ribose transfer". Without OA,
reserves of PRPP are typically very low, given the limited capacity of
this pathway. The generation of ribose-5-phosphate (R-5-P - the
immediate precursor to PRPP ribose supply) is enhanced with OA and as a
result - greater ATP is realized.
2.) OA increases the pool of Uridine Monophosphate/Cytidine
Monophosphate (UMP/CMP). By increasing levels of these nucleotides the
demand on ATP reserves to synthesize them is decreased. The end result
is more ATP being available for functions important to us - such as
greater energy and muscle contractile force.
3.) OA elevates intracellular glycogen stores, via greater glucose
disposal into muscle tissue. In other words, it leads to more efficient
glycolysis* (Kypson et al. 1978).
*Glycolysis literally means "splitting
sugars." In glycolysis, glucose (a six carbon sugar) is split into two
molecules of a three-carbon sugar. Glycolysis yields two molecules of
ATP (free energy containing molecule), two molecules of pyruvic acid
and two "high energy" electron carrying molecules of NADH. The more
glucose stored in muscle, the more ATP can be generated via this
MASS PRO Synthagen builds and maintains optimal ATP levels in both
muscle/non muscle cells, giving the "green light" for the body to thrive. As an added bonus, Orotic Acid picks up where Peak ATP leaves
off - allowing you to push harder and longer by virtue of the fact it
1.) quickly resynthesizes ATP levels and 2.) improves anaerobic
glycolysis. The first 10 seconds or so of intense effort are fueled by
ATP, the next 2 minutes by glycolysis. Synthagen ensures all your
energy systems are fully fueled and replenished lightening fast. You'll
be able to push harder, longer and much stronger.
The right way to
has been made
recently of Beta-Alanine (BA), the precursor to carnosine and its
ability to "buffer" pH - leading to better muscular endurance. Once
again, the Russians were way ahead of the game - identifying carnosine
and its benefits as long ago as 1900.
Nevertheless, when you study
and its ultimate metabolic fate, you'll notice something -
others have missed. Greater muscle carnosine levels are not BA's only
benefit, because it's yet another
powerful substrate that can be used to accelerate protein synthesis.
Here was the clue, leading to
"Subsequent to an
inhibitor (6-azauraci) being given to animals used in the experiment,
an enormous increase in BA uptake (70%) and corresponding increase in
carnosine synthesis takes place in the muscle cell..." (19)
(19) Aonuma S, Hama T, Tamaki N, Okumura H.
(1969) Orotate as a
-alanine donor for anserine and carnosine biosynthesis and effects of
actinomycin D and azauracil on their pathway. J.Biochem. 66: 123-133.
What does this tell us?
It demonstrates that ß-Alanine CAN be used for RNA/greater
synthesis and ultimately more muscle. The operative word here
is "can". In other formulas, the contribution BA can make is limited,
given it's usually used only to boost carnosine concentrations. Its
ability to play a role in accelerating muscle growth is therefore
limited, if non-existent.
It stands to reason that if growing new muscle is way down on your
body's priority list (and it is, from your body's perspective), the
majority of BA provided in most supplements will NOT be used to grow
Instead, it will combine with
the amino acid
L-Histidine to form Carnosine. Recall L-Histidine is one of the
essential amino acids, and a deficiency of just one EAA stops protein
synthesis in its tracks. In the typical standalone Beta-Alanine
supplement example, protein synthesis takes it on the chin not once,
but twice. First, BA is not made available for use as an RNA substrate,
L-Histidine isn't included for incorporation into building new
contractile muscle proteins.
The ideal then, is to boost Carnosine
where you can realize the performance enhancement and
muscle growth benefits of each. In fact, research has indicated that
the combination of Carnosine and Beta-Alanine offers even MORE to the
athlete than previously elucidated: Two very desireable benefits - It
promotes tissue repair and also accelerates wound healing (20).
With this strategy set, you'll no longer have to settle for just 1/3rd
of what ß-Alanine has to offer. Instead, the MASS PRO Synthagen formula allows you to have it ALL-
well established pH buffering/better endurance benefits via muscle
tissue repair and wound healing
• ß-Alanine now being in the correct environment for accelerated
MASS PRO Synthagen
elevates muscle carnosine concentrations via a different nutraceutical,
to free up Beta-Alanine for a higher purpose - accelerated protein
Which brings us to...
Asparate - Widespread Deficiency
This is one mineral that matters, given the following: A study
sponsored by the National Institutes of Health showed that 68% of
Americans are magnesium deficient. Other experts put the number closer
80%. Whatever the case, it's clear that correcting what amounts to a
widespread deficiency holds massive potential for many reading this.
What makes this situation potentially worse for the athlete, is that
considerable evidence exists that exercise makes this situation even
worse. Increased loss of magnesium from the body is seen during and
after exercise. Specifically, a shift in magnesium from the plasma into
erythrocytes was found. In fact , the more anaerobic the exercise (i.e.
weight training), the greater the movement of magnesium. Many other
research studies show that serum magnesium levels are reduced in
response to exercise/strength training.
We're talking about a mineral involved in over
300 enzymatic reactions - including glycolysis, the krebs cycle, creatine
phosphate formation, nucleic acid synthesis, amino acid activation,
cardiac and smooth muscle contractability, cyclic AMP formation, and
most importantly for our purposes - protein synthesis.
Magnesium supplementation has been shown to improve cellular metabolism
in competitive athletes. In one clinical trial which studied the
effects of magnesium supplementation (360 mg/day) for 4 weeks in male
competitive rowers showed a decrease in serum lactate concentration and
oxygen consumption when compared to those receiving a placebo. In other
words, the results of this study
suggested that magnesium supplementation has a beneficial effect on
energy metabolism and work efficiency.
It has also been noted in research studies that maximal contraction of
the quadriceps is positively correlated to serum magnesium status.
Further, a 1992 study published in the Journal of the American College
of nutrition entitled Effect of Magnesium Supplementation on Strength
Training in Humans studied the effects of a dietary magnesium
supplement (magnesium oxide* given in a ratio of 8 mg/kg/day including
dietary magnesium) on strength development during a double-blind, 7
week strength training program in 26 untrained subjects. There was a
magnesium supplemented group and a control or placebo group.
The results of the
study showed that the oral magnesium supplementation group produced
significantly greater results in strength than the control group.
The researchers also concluded that magnesium's role in protein
synthesis may be at the ribosomal level**.
* You'll note this study used the inferior
OXIDE form of Magnesium, which isn't nearly as well absorbed as the
ASPARATE version MASS PRO Synthagen uses. Thus, the much higher mg.
amount needed. Safety studies in England concluded that magnesium
aspartates demonstrate greater oral absorption and bioavailability
compared to less soluble magnesium preparations such as magnesium
oxide, magnesium hydroxide, magnesium carbonate and magnesium sulphate.
** Given Magnesium's role in protein synthesis appears to act primarily
by activating amino acids and attaching mRNA to the ribosome, optimal
Magnesium levels in athletes using Ecdysterone is absolutely critical.
Like Magnesium, Ecdysterone speeds up activity in the ribosome, again
from available amino acids.
MASS PRO Synthagen is the first and only formula to leverage this information, and contains the most efficacious ratio of ALL necessary Amino Acids, Magnesium and Ecdysterones in their most bioavailable forms.
ATP Phosphate Transfer is the fastest source of muscular energy, and the Synthagen Substrates super bioavailable Magnesium turns on the switch...
ATP (adenosine triphosphate or energy) is always present as a
Magnesium/ATP complex. Magnesium provides stability to and binds to
phosphate groups in ATP, thus making a complex that aids in the
transfer of ATP phosphate. Since working muscles generally contain more
ADP (adenosine diphosphate), allowing ATP to release a phosphate group
means more power during your workouts.
Magnesium is also a co-factor to the enzyme creatine kinase. Here's why
that's important. Creatine kinase helps phosphocreatine combine with
ADP to resynthesize ATP subsequent to contractile activity. What is
also little known, is that phosphocreatine possesses a higher phosphate
group transfer potential than even ATP itself, thus providing an
even faster source of muscular energy during training.
Once again, MASS PRO Synthagen has you covered. Rosenfeldt et al. (1998) (21) showed
under hypoxic conditions (typical, following anaerobic exercise)
elevation of uridine levels increased muscle phosphocreatine and
creatine levels 38% and 3%, respectively. Synthagen uses Orotic Acid to
accomplish this, and the most bioavailable form of Magnesium to unlock
the fastest source of muscular energy you can tap into.
(21) Rosenfeldt FL, Richards SM, Lin Z, Pepe
S, Conyers RAJ. (1998) Mechanism of cardioprotective effect of orotic
acid. Cardio.Drug.Ther. 12: 159-170.
MASS PRO Synthagen will increase your anaerobic threshold by tapping
into your fastest muscular energy source (phosphocreatine) - allowing
you to train faster, harder and longer than your competition. It does
so by providing you with effeciently absorbed Magnesium Asparate, a
mineral necessary to maximize Synthagen's protein synthesis and
cellular energy stoking qualities.
Glycine "AKA Betaine"
Tri-Methyl Glycine is a well known methyl-doner and efficient precursor
to the super-nutrient Sam-E.
Sam-E plays a very important
role in the body and is central to synthesizing polyamines (22).
Downstream, the polyamines known as spermidine and spermine are formed.
These particular polyamines are involved in the control of cell growth (23)
and have also been shown to have analgesic and anti inflammatory
Like Orotic Acid, TMG is used
in farm animals to imrprove muscle to fat ratios. Looking closer at
this research, TMG appears to aid in lipid metabolism by sparing
choline. The saved choline is then used for lecithin synthesis, the
mechanism via which fat is transported. The key point being made here,
is that methylation which occurs in the liver is almost entirely
responsible for repairing, renewing and re-generating not only existing
lean body mass and fat loss mechanisms, but in synthesizing new muscle tissue as
There is another little known TMG benefit- it helps re-synthesize RNA. RNA re-synthesis is heavily dependent upon the availability of these methyl groups. In fact, methylation is an incredibly overlooked component of muscle growth and needs to be optimized given an attempt at growing new muscle as fast as possible.
Building upon the aforementioned animal research, there is also recent
(2011) data surrounding TMG's potential to increase anabolic hormones,
decrease catabolic hormones and improve muscle force production and
endurance in HUMANS (25). In fact, this particular
paper's conclusion is quite striking;
supplementation increased force production and muscular endurance.
These performance measures correspond to increases in anabolic hormones
(GH and IGF-1) and maintenance of anabolic muscle signaling (Total Akt,
Akt and p70 S6k phosphorylation) responses, as well as the
decrease in catabolic hormone (cortisol) and inhibitory muscle
signaling (AMPK phosphorylation) following 14 days of betaine supplementation"
Of particular note here
(page 50), is TMG's ability to sustain protein synthesis, whereas in
those not receiving TMG - the process slowed/stopped.
"The increase in
Akt Total pre and post-exercise, as well as the maintenance in Akt S473
post-exercise following betaine supplementation indicates a greater
ability to signal further downstream. These results correspond to the
increase in GH and IGF-1 AUC during the betaine supplementation.
Although there was no change in p70 S6k Total, p70 S6k T389
phosphorylation was maintained during the betaine supplementation pre
and post-exercise. The decrease in p70 S6k T389 during the post placebo
supplementation trial is explained partially by the increased cortisol
levels during this time, where the maintenance during betaine
supplementation is explained by the decrease in cortisol levels and
therefore decreased inhibition to the muscle signaling pathway.
Furthermore, the decrease in AMPK phosphorylation observed would
decrease the inhibitory effect on the mTOR pathway, allowing a more
positive anabolic signal. In total, these observations suggest
maintenance of protein synthesis during a concurrent workout, and
provide a cellular basis to the ergogenic effect of betaine
builds upon RCE's strengths
For those familiar with the Rob Regish writings in The Blueprint 2.0,
he theorized in 2009 that Ecdysterone worked via the PI3K/AKT pathway.
Now, subsequent research carried out at Rutgers has confirmed this (26).
"Phytoecdysteroids, structurally similar to insect molting hormones,
produce a range of effects in mammals, including increasing growth and
physical performance. In skeletal muscle cells, phytoecdysteroids
increase protein synthesis. In this study we show that in a mouse
skeletal muscle cell line, C(2)C(12), 20-hydroxyecdysone (20HE), a
common phytoecdysteroid.... elicited a rapid elevation in intracellular
calcium, followed by sustained Akt activation and increased protein
synthesis. The effect was inhibited by a G-protein coupled receptor
(GPCR) inhibitor, a phospholipase C (PLC) inhibitor, and a
phosphoinositide kinase-3 (PI3K) inhibitor."
Both nutraceuticals in MASS PRO Synthagen act favorably by activating and sustaining AKT and
other growth mechanisms. TMG also adds the "punch" of increased GH and
IGF-1 and slashes cortisol levels.
This tips the scale to where
anabolism vastly outweighs catabolism, and thus, muscle is rapidly
synthesized and the entire process sustained fantastically verses
without TMG. THIS is how new muscle is grown, at the fastest
rate your physiology will allow.
BOTTOM LINE ON TMG:
• Re-synthesizes RNA
• Decreases inflammation
• Increases GH/IGF-1
• Maintains total Akt, p70 S6k and mTOR signaling during
• Decreases cortisol
• Re-invogorates and maintains protein synthesis
• Is a key osmotic/cellular hydration ingredient
• Enhances muscle fullness
• Acts as an energy enzyme protector
• Induces the conversion of homocysteine to methionine
• Elevates glutathione levels
• Promotes liver health
• Helps maintain intracellular electrolytes
(22) Herby O. Role of polyamines in the
control of cell proliferation and differentiation. Differentiation
(23) Oyanagui Y. Anti-inflammatory effects of polyamines in serotonin
and carrageenan paw edemata possible mechanism to increase vascular
permeability inhibitory protein level which is regulated by
glucocorticoids and superoxide radical. Agents Actions 1984;14:228,37.
(24) "Influence of Betaine on Pasture, Finishing and Carcass
Performance in Steers,"; 2004 by Professional Animal Scientist.
(26) Steroids. 2010 Oct;75(10):632-7. Epub 2010 Apr 2.Ecdysteroids
elicit a rapid Ca2+ flux leading to Akt activation and increased
protein synthesis in skeletal muscle cells.Gorelick-Feldman J, Cohick
W, Raskin I. Biotech Center, Cook College, Rutgers University, 59
Dudley Road, New Brunswick, NJ 08901, USA.
In whole, MASS PRO Synthagen benchmarks an all-new category:
OMNI-POTENT NUTRITION OPTIMIZATION.
MASS PRO Synthagen
draws upon 19 years of Muscle And Sports Science® innovations, combined with the cutting-edge research and weight room winning insights of Coach Rob Regish (Author of "The Blueprint for BIG Muscle Building" and
weekly Super Human Radio Contributor).
MASS PRO Synthagen advances nutrition optimization and sports enhancement to a virtually fail-proof region, because it "auto-corrects" so many common pitfalls that can occur with anyone's training, diet and supplementation - even top pro athletes.
Which brings us to Rob Van Dam, who urged us to develop something fast and effective which can be easily used on the fly by on-the-go athletes, too often stuck with
less than optimal food options. The Yin/Yang cap design is a nod of appreciation to RVD for his contributions to the ProtoGeneX™ project.
To elaborate more on this
aspect, MASS PRO Synthagen has the unique quality of "upgrading" other nutrients/foods
by filling in key missing elements and actions no one has addressed before.
This stuff can boost fast foods in a pinch and "complete" them into something the body can use and even excel with, proven in "harshest junk food conditions" testing by Rob Regish. So, just imagine what it can do combined with the high quality foods and top shelf supplements we smart athletes strive to partake of!
Optimal use of MASS PRO Synthagen allows the savvy to refine their food and supplement choices to a central "best of the best" core and see better results than ever before. Isn't it time YOU reaped bigger rewards?
At MASS, an educated customer is our best customer. Our goal is to deliver the real results you want, and for you to tell your friends and family how well our world class supplements deliver exactly what is promised, and then some. Since 1993, we've been The Trusted Source. Real MASS. Real RESULTS.
MASS PRO Synthagen™, we firmly believe, will prove itself so strongly to you that it becomes a core companion performance booster you'll never want to be without. One single bottle of "MPS" will convince you, long before the bottle is even half finished. Three bottles might find you contending with the best in your sport, or folks asking you about "your youth serum secret".
Reserve your MASS PRO SYNTHAGEN, shipping now! This high demand item is first come, first served as all prior batches have sold out in record time. To avoid future delay, lock in your supplies TODAY.
HERE to claim your personal supply of New MASS PRO Synthagen
• NEW: MASS PRO Synthagen 'Q&A Review' - Master Level Trainer dosing schedules
• Detailed INFO on MASS brand targeted amino acids and POWERHOUSE proteins
"If you are going to invest in only one product for your health, muscle building, sports performance,
longevity and anti-aging benefits - this is it!" -Rob Regish, appearing on Super Human Radio
"This is my base supplement from here on. I just can't believe how I gained strength. This run allowed me to push the extremes of high, low, and no calorie days, mess up a bit yet still be successful. The overall single best bodybuilding supplement I have personally ever used." -Thicketman, Bodybuilding Forum review
"Exceptional product! Far exceeds anything else on the market. Increased work capacity, increased recovery/reduced muscle soreness! Definite game changer." -Donnie Morrison, Ridgecrest, CA
The restorative properties and increased sense of well being is amazing!! Not only can you train harder and increase intensity/density, you wake up the next day with no soreness and ready to train again. You have to literally force yourself to not train on days you are supposed to take off. For those who are wanting to train on the next level, this product will take you there." -Gareth Denyer, CPT, HCP Barbell, Woodlands, TX
"Worth every penny." -Ameer Rosic, Toronto, Ontario Canada
"How did you do it? Never used anything except deca and anadrol that made such a difference in how I feel related to the recovery process. Can I buy stock in it? Congratulations." -Dave, San Luis Obispo, CA
"I thought of that while riding my bike." -Albert Einstein,
On the Theory of Relativity